====== AlphaFold & Co ====== On the cluster, you can find different software to make structure prediction from primary sequence. The main one is Alphafold and it's derivatives, all based on Multiple Sequence Alignment (MSA). Others are based on a Protein Language Model (PLM) which don't require any MSA or co-evolution data. ^ Software ^ Version Installed ^ Method ^ Multimer mode ^ Documentation ^ Github ^ | Alphafold | 2.3.1 | MSA | yes | [[cluster-lbt:extra-tools:alphafold_tool|Wiki]] | [[https://github.com/deepmind/alphafold|Link]] | | Colabfold | 1.5.2 | MSA | yes | [[cluster-lbt:extra-tools:colabfold|Wiki]] | [[https://github.com/sokrypton/ColabFold| Link]] |  | Omegafold | 1.1.0 | PLM | no | [[cluster-lbt:extra-tools:omegafold|Wiki]] | [[https://github.com/HeliXonProtein/OmegaFold| Link]] |  | ESMFold | 1.0.3 | PLM | yes | [[cluster-lbt:extra-tools:esmfold|Wiki]] | [[https://github.com/facebookresearch/esm| Link]] |  ===== CASP14 Example ===== {{ :cluster-lbt:extra-tools:toto.png |}} Here a result of [[https://predictioncenter.org/casp14/target.cgi?id=46&view=all|T1050]] 779 residus protein, a CASP14 target ([[https://predictioncenter.org/casp14/results.cgi?view=tables&target=T1050|CASP14 results]]). ===== Troubleshooting ===== In case of trouble, you can contact me at : ''hubert.santuz[at]ibpc.fr''