Table des matières

AlphaFold & Co

On the cluster, you can find different software to make structure prediction from primary sequence.

The main one is Alphafold and it's derivatives, all based on Multiple Sequence Alignment (MSA). Others are based on a Protein Language Model (PLM) which don't require any MSA or co-evolution data.

Software Version Installed Method Multimer mode Documentation Github
Alphafold 2.3.1 MSA yes Wiki Link
Colabfold 1.5.2 MSA yes Wiki Link
Omegafold 1.1.0 PLM no Wiki Link
ESMFold 1.0.3 PLM yes Wiki Link

CASP14 Example

Here a result of T1050 779 residus protein, a CASP14 target (CASP14 results).

Troubleshooting

In case of trouble, you can contact me at : hubert.santuz[at]ibpc.fr