The effect of protein composition on hydration dynamics

TitleThe effect of protein composition on hydration dynamics
Publication TypeJournal Article
Year of Publication2013
AuthorsRahaman O., Melchionna S., Laage D., Sterpone F.
JournalPhys. Chem. Chem. Phys.
Volume15
Pagination3570–3576
Abstract

Water dynamics at the surface of two homologous proteins with different thermal resistances is found to be unaffected by the different underlying amino-acid compositions{,} and when proteins are folded it responds similarly to temperature variations. Upon unfolding the water dynamics slowdown with respect to bulk decreases by a factor of two. Our findings are explained by the dominant topological perturbation induced by the protein on the water hydrogen bond dynamics.

Citation Key2013|1956